Peptic Ulcer Research Today is a free monthly online journal that collates and summarizes the latest research about Peptic Ulcer, including details on helicobacter pylori, diet, symptoms, treatment.

Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers.

Ramadan S, Bonin AM, Kennedy BJ, Hambley TW, Lay PA

Centre for Heavy Metals Research, School of Chemistry, University of Sydney, NSW, 2006, Australia.

Acetonitrile extracts of ulcerated and control rat stomachs were studied by various NMR techniques in an attempt to understand how indomethacin, a common and powerful nonsteroidal antiinflammatory drug (NSAID), induces ulcers in the stomach. One- (1D) and two-dimensional (2D) NMR spectra of extracts of ulcerated and control stomachs revealed that glycolytic and Krebs cycle enzymes were partially inhibited in the ulcerated stomach as shown by the lactate/glucose ratio. The (total choline)/lactate ratio was also higher in the extract from the control stomach than in the ulcerated stomach. Glycerophosphoethanolamine and glycerophosphocholine concentrations were higher in the ulcerated stomach extract as compared with the control stomach extract. These results explain the gastrointestinal protective effect of D-glucose and Krebs cycle intermediates on NSAID-induced ulceration.

Published 21 February 2005 in Chem Res Toxicol, 18(2): 123-8.
Full-text of this article is available online (may require subscription).

© 2004-2008 Peptic Ulcer Research Today. All Rights Reserved.